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COBRApy is a package for constraint-based modeling of metabolic networks.

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From the mailing list: > Thank you! That is very helpful. If I add a reaction, the metabolites are also added (good!) but all reactions from the universal model associated...

bug
help-wanted

### Checklist ![mini cobra error 1](https://user-images.githubusercontent.com/89946704/180473613-c7ffd5f5-2aa4-470e-b372-a00cc42d884d.jpg) ![mini cobra error 2](https://user-images.githubusercontent.com/89946704/180473762-98dd1790-691a-4a50-b4d4-2c76ff99b7d3.jpg) ![mini cobra error 3](https://user-images.githubusercontent.com/89946704/180473876-994d935e-d3d1-4ffe-ab3a-037c9675baf2.jpg) - [ ] I searched the [documentation](https://cobrapy.readthedocs.io). - [ ] I looked through [similar issues on...

### Checklist - [ x] There are [no similar issues or pull requests](https://github.com/opencobra/cobrapy/issues) for this yet. ### Is your feature related to a problem? Please describe it. There are three...

enhancement
help-wanted
good first issue

Hi all, there are currently some issues with how annotations are stored in cobrapy. [1] MIRIAM qualifiers are dropped RDF annotations are triples of the form (subject - predicate -...

SBML

#### Problem description Reading a SBML model with ASCII codes in the IDs may generate invalid cobrapy IDs during parsing (for instance names including spaces). #### Code Sample That one...

SBML

In the discussion with @Midnighter it came up that there should be a generic support for compressed files for the various io modules. I.e. cobrapy should support the reading and...

enhancement

#### Problem description Using the `model.copy()` with the gurobi interface causes the upper bound of constraints to be overwritten. #### Code Sample ```python import cobra model = cobra.Model() model.add_metabolites(cobra.Metabolite('a')) model.metabolites.a.constraint.lb...

bug

### Checklist - [ ] I searched the [documentation](https://cobrapy.readthedocs.io). - [ ] I looked through [similar issues on GitHub](https://github.com/opencobra/cobrapy/issues). - [ ] I looked up "How to do ... in...

needs information

#### Problem description Please explain: I am trying to study the FBA output of a model, changing different growth substrates in the media. To do this, I'm mapping the solution...

stale

Starting with [the Recon3D model straight from BiGG](http://bigg.ucsd.edu/static/models/Recon3D.xml), which has all reactions set to a default upper bound of 1000, I changed some reactions to have upper bounds larger than...

bug
SBML