gnomad-browser

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Add FAQ "How many variants are in gnomAD?"

3

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Differentiate ClinVar variants with conflicting interpretations of pathogenicity

3

Currently, ClinVar variants with multiple interpretations are all labeled as "Conflicting interpretations of pathogenicity". On the variant page, details about each submission can be seen. On the gene/region/transcript pages, however,...

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Display information about how often multiple variants in certain categories occur together in the same gene.

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Add options for filtering variants

1

Allow filtering gnomAD variants list based on additional columns, such as clinical significance (#581) and flags (#400). Numeric columns, such as AC, should allow filtering to less than/equal to/greater than...

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Cache VEP annotations for ClinVar variants

1

Caching VEP annotations (instead of re-running VEP on all variants each time) would speed up the ClinVar pipeline. This would be nice for updating ClinVar data more frequently.

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Code split browser bundle

2

JS code for the browser is currently all bundled into one multi-megabyte file. The major pages (gene, region, variant, structural variant, etc) can be split into separate bundles and loaded...

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Separate "uncertain significance" from "conflicting interpretations of pathogenicity" and "conflicting data from submitters" in ClinVar track categories. https://atgu.slack.com/archives/CNLMF0JLV/p1614977312053800?thread_ts=1614722609.026400&cid=CNLMF0JLV

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Add raw quality metric histograms for gnomAD v3

3

gnomAD v3.1 has two versions of quality metrics histograms: one raw and one with low quality genotypes filtered out. Currently, only the latter is displayed in the browser. Field names...

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Demo deployments get very little traffic.

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