mutational-signatures topic

SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in e...

AlexandrovLab

🌲 An easy-to-use and scalable toolkit for genomic alteration signature (a.k.a. mutational signature) analysis and visualization in R https://shixiangwang.github.io/sigminer/reference/index.html

ShixiangWang

An R package for studying mutational signatures and structural variant signatures along clonal evolution in cancer.

FunGeST

SigProfilerMatrixGenerator creates mutational matrices for all types of somatic mutations. It allows downsizing the generated mutations only to parts for the genome (e.g., exome or a custom BED file)....

AlexandrovLab

highly-efficient & lightweight mutation signature matrix aggregation

carjed

Sigflow: Streamline Analysis Workflows for Mutational Signatures, https://github.com/ShixiangWang/sigflow/pkgs/container/sigflow

ShixiangWang

R wrapper for utilizing the SigProfilerMatrixGenerator framework

AlexandrovLab

SigProfilerPlotting provides a standard tool for displaying all types of mutational signatures as well as all types of mutational patterns in cancer genomes. The tool seamlessly integrates with other...

AlexandrovLab

SigProfilerSimulator allows realistic simulations of mutational patterns and mutational signatures in cancer genomes. The tool can be used to simulate signatures of single point mutations, double poin...

AlexandrovLab

SigMa is a probabilistic model for the sequential dependencies of mutation signatures

lrgr