scDRS

scDRS copied to clipboard

1. Check if the weights are negative. 2. Add description to emphasize the z-scores should be one-sided.

martinjzhang

Some users may use all scRNA-seq genes as the trait gene set as some sort of negative control. scDRS produced miscalibrated results in this case due to numerical issues. -...

martinjzhang

Dependency on Background Cells (followup)

3

Hey again, In the 7th discussion point of the manuscript you mention the possibility of choosing the control gene sets based on a different data set than the one you're...

NoahMottelson

Broader control gene sets

1

Hey, congratulations on your paper's acceptance! You mention in the Discussion that it might make sense when using specialized data sets to select matched control genes based on a broad...

kitscorp

Interpreting scDRS score when comparing cell-type subclusters

1

Hi, thank you for providing such a fantastic tool! It’s exactly what I needed for integrating GWAS summary data with scRNA-seq data. While using this tool, I encountered a question...

HyeonbinJoHCho

The relationship between cell type association and heterogeneity

1

hi, thanks for this powerful tool！ I did some analyses and have some questions about the interpretation of the results. Is the discussion of within-cell type heterogeneity premised on that...

AI-10

Correcting cell-level p-values for multiple comparisons?

3

Hi, thanks for a great package! I am working with a brain snRNAseq dataset and have run scDRS to test for the enrichment of MDD, ADHD, ALZ, MS, SCZ, and...

schroeme

Issue with plot using scdrs.util.plot_group_stats

1

Hello, I am working with some GWAS data along with the TMS Facs mouse single cell dataset. I am trying to create the cell heterogeneity plot based on the tutorial,...

NaomiHuntley

Identical assoc_mcp in results

12

Hi @martinjzhang , I have used scDRS (great tool, thank you!) to score a single cell dataset against a list of genes related to a disease (obtained from GWAS sum...

auesro

scDRS analysis on a large single-cell RNA-seq dataset

3

hey, I am trying to run scDRS on a single-cell data containing three million cells, but the analysis failed due to server memory limitations. Are there any alternative ways to...

AI-10