scDRS
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scDRS breaks if using all scRNA-seq genes as disease genes
Some users may use all scRNA-seq genes as the trait gene set as some sort of negative control. scDRS produced miscalibrated results in this case due to numerical issues.
- Raw control scores were slightly but systematically smaller than the disease score (1e-17).
- Small SD of raw control of a given cell across control gene sets (1e-18).