pgaudet

Thanks for bringing that up @huaiyumi One issue I can see is that [GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity](https://amigo.geneontology.org/amigo/term/GO:0022848#display-lineage-tab) is not a signaling receptor activity, but only a [GO:0022857 transmembrane...

@balhoff This seems like a logical problem ? only in bacteria should be disjoint from only in eukaryotes, shouldn't it ?

Hi @balhoff The TC is not in the manually edited file (only_in_taxon). As @ValWood points out, it looks like the "Viridiplantae or Bacteria or Euglenozoa" constraint was added in this...

We already have [chromatin-protein adaptor activity](http://purl.obolibrary.org/obo/GO_0140463) We could add a synonym? I imagine we are describing the same activity?

But then we still need to specify 'genomic DNA I suppose? To avoid annotating to TLR type activities that detect DNA in the cytosol?

@colinlog and I propose that the term label would be '**dbTF DNA binding stabilizer activity'** (or, 'DNA binding transcription factor DNA binding stabilizer activity') with the definition that @colinlog proposes...

Definitely the BPs should be obsoleted. WRT MFs: these terms were created to represent 'caspase activity', but the intention was not to explicitly name 'caspase' because that represents a gene...

@raymond91125 Would you please run an annotation review so we can decide how to proceed?

It looks like people have not yet reviewed their annotations. Can you ping them? We cannot automatically assign the annotations to 'regulation of apoptotic process' or 'apoptotic process'. Thanks, Pascale

Hi @raymond91125 GO:2001056 positive regulation of cysteine-type endopeptidase activity should also be obsoleted, as a single step BP. This could perhaps be replaced by [cysteine-type endopeptidase activator activity](http://purl.obolibrary.org/obo/GO_0140608), if this...