paturley

I'm confused by your question. You are using MTAG within an ancestry across several traits and then you'd like to meta-analyze with a trait across ancestries? On Wed, Jan 3,...

This sounds reasonable to me. I can't think of why you shouldn't be able to do this (though sometimes I'm not creative enough to anticipate problems that I haven't tested...)...

I think that the likely issue here is that both of your phenotypes are quite low powered, so the estimates of Omega and Sigma are noisy. Omega may be thought...

I am also confused. What's the SE on the LDSC estimate? Can you post the complete MTAG log? On Wed, Jan 3, 2024, 9:24 PM Isaac ***@***.***> wrote: > I...

Hmm. It's very odd to me that MTAG is producing a negative genetic correlation when LDSC is getting a positive one. Can you calculate the variance-covariance matrix of your z-scores...

You just need to make sure the reference alleles align in the two sets of summary statistics and then calculate the variance of each z-stat column and the covariance between...

Sometimes MTAG gets confused about what columns are what. Do you have many more than the required columns in your summary statistics file? On Tue, Oct 31, 2023, 3:49 AM...

Hello Chen, A few responses: 1) In the MTAG paper, we describe each set of summary statistics as corresponding to their unique trait. In practice, MTAG will be better powered...

1. The order of the input GWAS should not matter 2. MTAG summary statistics are (in expectation) the same as what you would obtain if you had just increased the...

We didn't test this formally in the MTAG paper, so a don't have a very rigorous answer for you. I remember seeing a MTAG on IQ (Hill et al maybe?)...