mtag icon indicating copy to clipboard operation
mtag copied to clipboard

Please check this level of improvement is normal?

Open Y-Isaac opened this issue 7 months ago • 12 comments

It is a really nice software, thanks. I use MTAG for two phenotypes(quantitative data), they are similar in mean chi2, heritability and N. The improvement in the result is a little huge, which makes me a little nervous, and the samples are nearly completely overlapping. But the FDR result looks is OK? (To be honest it's a little hard for me to comprehend the section on FDR in your paper. Can I simplify it by understanding that if the maximum FDR values for all phenotypes are below 0.05, it indicates a relatively reliable outcome?) Please help me to check this result. Here is the log file:

Summary of MTAG results:

Trait # SNPs used N (max) N (mean) GWAS mean chi^2 MTAG mean chi^2 GWAS equiv. (max) N 1 ../trait1_int_mtag.txt 4842156 25204 22652 1.050 1.403 201652
2 ../trait2_int_mtag.txt 4842156 25164 22617 1.041 1.380 231579
Estimated Omega: [[ 1.742e-06 -9.010e-07] [-9.010e-07 1.167e-06]]

(Correlation): [[ 1. -0.632] [-0.632 1. ]]

Estimated Sigma: [[1.05 0.817] [0.817 1.051]]

(Correlation): [[1. 0.777] [0.777 1. ]]

Maximum FDR Max FDR of Trait 1: 0.0239762500984 at probs = [0. 0.4 0. 0.6] Max FDR of Trait 2: 0.0413134475532 at probs = [0. 0. 0.4 0.6]

Y-Isaac avatar Jan 03 '24 04:01 Y-Isaac