mtag
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Please check this level of improvement is normal?
It is a really nice software, thanks. I use MTAG for two phenotypes(quantitative data), they are similar in mean chi2, heritability and N. The improvement in the result is a little huge, which makes me a little nervous, and the samples are nearly completely overlapping. But the FDR result looks is OK? (To be honest it's a little hard for me to comprehend the section on FDR in your paper. Can I simplify it by understanding that if the maximum FDR values for all phenotypes are below 0.05, it indicates a relatively reliable outcome?) Please help me to check this result. Here is the log file:
Summary of MTAG results:
Trait # SNPs used N (max) N (mean) GWAS mean chi^2 MTAG mean chi^2 GWAS equiv. (max) N
1 ../trait1_int_mtag.txt 4842156 25204 22652 1.050 1.403 201652
2 ../trait2_int_mtag.txt 4842156 25164 22617 1.041 1.380 231579
Estimated Omega:
[[ 1.742e-06 -9.010e-07]
[-9.010e-07 1.167e-06]]
(Correlation): [[ 1. -0.632] [-0.632 1. ]]
Estimated Sigma: [[1.05 0.817] [0.817 1.051]]
(Correlation): [[1. 0.777] [0.777 1. ]]
Maximum FDR Max FDR of Trait 1: 0.0239762500984 at probs = [0. 0.4 0. 0.6] Max FDR of Trait 2: 0.0413134475532 at probs = [0. 0. 0.4 0.6]