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evolutionaryscale
Hi, Many proteins naturally exist in pairs, often referred to as alpha and beta chains, such as TCRs, antibodies, and MHCs. I’m curious about how ESM3/ESMC processes these cases. -...
thank you for reading this issue Can anybody use the esm3-large-2024-03(98B）model ? "{"status":"error","message":"User does not have access to model"}" I cant't use this model ,please help me ,thanks
What is the expected way to perform function prediction? I read the class and noticed that if we provide even one , all other residues without a specified function are...
Hi Evolutionaryscale team, I'd like to fine-tune larger version of ESM3, most possibly the medium one. It seems like the model accessed from Forge wouldn't allow that. I'm wondering if...
Hi there, I would like to generate embedding for a protein sequence that comes from a multiple sequence alignment (e.g: "AAA--AAA--A") What kind of token should be used to describe...
For the all-atom direction loss, the description in the paper is as follows: “For each atom with at least two covalent bonds, compute a normal (z-axis) vector to the plane...
Hello, I'm currently working with the code in the /esm/esm/utils/structure/affine3d.py file. I noticed that there is no logic related to torsion angles in the code. For example, although the predict_torsion_angles...
Hi, Thank you for your model. I have a quention: I ues ESM3 to get peptide's embedding, and then, I want to map the embedding through the language modeling head...
In your report, the ESM C 6B model has a P@L significantly higher than ESM2 15B. I am hoping to investigate what are these contacts that the smaller models failed...
I'm looking forward to fine - tuning ESMC by incorporating other specialized knowledge. Could you please tell me how to achieve that?
