Aaron Quinlan

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I think this is a very interesting idea. I will dig into this a bit next week and follow up soon.

@ryanlayer and @brentp what do you think?

So sorry for the delay. We all feel that this would be a very valuable addition and would pave the way for future similarity metrics / approaches that we are...

Waas the process killed because of too much memory or too long of a run time on a cluster? I am not able to help without more information.

![image](https://user-images.githubusercontent.com/72291/136832736-a0724d3e-3cbb-4f98-9ac7-e7f7dd48b0c1.png) Agreed. For example, weight 3, 1, and 5 by the number of overlapping base pairs, correct?

Got it. I will look into it, but I think all of the tooling is in place for this. Thanks for the nice suggestion.

I will plan to add this for the next release.

Zeros should be part of the weighted mean for the uncovered positions, right?

I drafted a version of this a few months ago but ran into some algorithmic challenges. Will try to revisit.

This is a nice idea and I will try to incorporate a solution in the release following the one I am about to drop. I need to think about how...