Paul Grosu

I would be very careful when using `required` when defining a protobuf message - please take at the following note as [required is forever](https://developers.google.com/protocol-buffers/docs/proto): > :exclamation: **Required Is Forever** You...

Hi David, Think of the bigger picture, what are we really interested in? We want to analyze clean quality-controlled groupings of data (reads, variants, etc.) for clinical purposes (i.e. disease...

Hi David, The issue is not that it is optional, but that a `Readgroup` can belong to multiple `ReadGroupSets`. If it belongs to multiple ones, does that mean we have...

I greatly welcome the idea of a demo, as it is my [preferred approach](https://github.com/ga4gh/server/issues/10#issuecomment-68998501). It will give us the opportunity to hash out and test ideas together for integrating the...

Hi David, I'm assuming the demos will be presented via Github. While you are building the demo try to see if generating temporary federated tables might help you in joining...

@david4096 I have ways to test things on a multi-node cluster where the distributed repositories would be simulated by throttling the bandwidth among running processes. There are tools like [Pipe...

I am in favor of controlled vocabulary, since it will makes searches more robust. This will allow for the possibility of find something similar to your phenotype search. The only...

A very sensible and welcome recommendation! Thank you and looking forward to the demo, Paul

I agree with all of the above, and it is great to see us push new boundaries such as through [gRPC](http://www.grpc.io/) as [recently updated](https://groups.google.com/forum/#!topic/ga4gh-dwg/DySUZKCM1xE) by @calbach through his [white paper](https://docs.google.com/document/d/1t42gQt3tcTyHJrMMCAIi8NPST14wWRqcbClNlBos3tg/edit)....

Well, the good news is that there is already a way that has been kindly prepared for us by Google. At the beginning of July they published a very nice...