pgaudet

There was a problem with the P2GO taxon checks. Please wait for the next report and re-open if the issue comes back. Thanks, Pascale

Hi @ValWood We write the reactions in the same way as RHEA/EC. In this case you can see in RHEA that most proteins catalyze the reverse reaction: https://www.rhea-db.org/rhea/15989 Reactions are...

According to wikipedia this is just a general property of PDE: https://en.wikipedia.org/wiki/PDE1 I think you can merge into GO:0004112 | cyclic-nucleotide phosphodiesterase activity Thanks, Pascale

GO:0004120 name: photoreceptor cyclic-nucleotide phosphodiesterase activity -> no reference, no annotations; I would obsolete that one, it does sound like a substrate - see Q14028. Thanks, Pascale

> @pgaudet what about the ' calmodulin-dependent cyclic-nucleotide phosphodiesterase activity'? Se my comment above https://github.com/geneontology/go-ontology/issues/20117#issuecomment-707746250 I suggest a merge.

@raymond91125 @hattrill and I have reviewed this in the context of the signaling work. We agree these should be kept. I fixed the EC xrefs. See useful review here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880502/...

Hi @sylvainpoux Is there a RHEA that corresponds to GO:1990404 protein ADP-ribosyltransferase activity and to ~GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity?~ (we have a RHEA for GO:0106274) Thanks, Pascale

What about NAD/NAPD: we have the 3 terms in GO * GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity * GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity = RHEA:19149 * GO:0106275 NADP+-protein-arginine ADP-ribosyltransferase activity = RHEA:54884 However:...

Thanks both!

- [x] GO:1990404 protein ADP-ribosyltransferase activity: changed label to NAD+-protein ADP-ribosyltransferase activity (consistent with definition, The transfer, from NAD, of ADP-ribose to a protein amino acid residue.) - [x] Fixed...