Vahid Ghayoomie
Vahid Ghayoomie
Some key ion channels for muscle cells and motorneurons are discussed under [this issue](https://github.com/openworm/muscle_model/issues/63#issuecomment-280926824).
Actually, this could be a beautiful example of proofing how traditional Hodgkin-Huxley approach fails to model such a curve for single-channel modeling! As could be inferred from this figure, Channelrhodopsin-2...
@rgerkin, As I remember the intention of this issue was to starting with a case-study for parameter optimization using voltage-clamp (assuming the initial voltage is unknown). We have the same...
@slarson, yes, makes sense. So we can have such a model, considering a time range from stimulation start time to stimulation end time, and do not struggle with deactivation tau...
OK, as a case-study for Vclamp optimization via cwFitter, this was really interesting for me, so I decided to take a look at this (sorry @rayner if you were working...
@pgleeson, thanks for the links and hints, will consider for the new models. The model also needs some improvements, considering some constraints claimed by the author, am working on this...
@pgleeson, Regarding the optimization process in c302 project, is there anything I can help with? That's also really interesting for me (definitely will spend some time in the near future...
As for this issue, I guess [this line](https://github.com/openworm/muscle_model/blob/master/BoyleCohen2008/PythonSupport/Main_Version/compareToNeuroML2.py#L156) should be replaced with `nml2_thiCa = ca_pool.restingConc / nml2_t_ca * get_si_value(densities['ca_boyle_all']) * nml2_Cmem` . But my comment, was relating to another problem...
Sorry, I didn't try to test my suggestion for this issue when I was commenting. When I replace this line `nml2_thiCa = get_si_value(ca_pool.restingConc) / (nml2_t_ca * get_si_value(densities['ca_boyle_all']) * nml2_Cmem *...
@pgleeson, Is there a way that I can solve the error I mentioned by myself? or this requires some change in the NeuroML2 format? I remember we had another problem...