Error in solve.default(t(D.weight) %*% D.weight) : system is computationally singular: reciprocal condition number = 1.20065e-19

[faeneeR]

Thanks for you powerful pachage.

Here, when I followed the tutorial for Estimation of cell type proportions with pre-grouping of cell types, I met an error.

And I don't know how to fix it. Eager to receive your reply.

Thanks a lot!

[JoyOtten]

I have the same issue right now, were you able to solve it?

[yeaon615]

When I encountered this issue, I also faced it when selecting a repeated cell type. The error disappeared when I chose a cell type that was not repeated.

[yeaon615]

When I encountered this issue, I also faced it when selecting a repeated cell type. The error disappeared when I chose a cell type that was not repeated.

However, I noticed that your issue occurred after running several samples, while mine occurred when running the first sample. It's possible that our reasons for the problem are different.