Stephan Schiffels

Very odd... could be phasing, which is ignored for `-I 0,1` and `-I 2,3` but not for `-I 0,1,2,3`. But hard to say in general.

Well, the first analysis just has some bizarre blow-up effect in a time-window, which doesn't look good. If you plot it on a scale from 0 to 1 you should...

> Hi, I'm doing some population demographical analysis among three populations, and I have two questions I'd like to ask for help. > > 1. There is only one individual...

No, you can't analyze a homozygous genome alone. You can of course treat a homozygous genome as a single haplotype and combine it with other such genomes to create something...

Yes, if it is recombining. If not, then you don't need MSMC, you can just use any phylogenetic software or build a neighbour-joining tree.

I will try and reproduce this, will be in touch.

OK good. As for interpreting the rCCR: This can happen, perhaps due to bad phasing, or simply because of bad estimates of population sizes. The rCCR is simply the ratio...

I don't understand. If you have empty multihetsep files, you need to obviously exclude them, because they provide no information. Or does that not solve the issue?

Hi @hungweichen0327. 1) Definitely not scale. You can just plot it without `ylim` and see how it looks. 2) no clear answer. Try both. In my experience, for population size...

It seems the linker can't fine GLIBC. I can't really support that. Have you tried one of the precompiled executables in releases? https://github.com/stschiff/msmc2/releases/tag/v2.1.4