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Question about aatype passed to AF2 structure module during design

Open tsjain opened this issue 3 months ago • 0 comments

For the soft or logit design phase, how is the aatype information passed to AF2 structure module?

I believe that part needs discrete amino-acid identities in order to assign frames for all the torsions, etc.. I believe that since the pLDDT loss also depends on the state from the structure module, the aatype input would impact the pLDDT values as well.

Thanks.

tsjain avatar Oct 02 '25 00:10 tsjain