Sebastian Frechen

The retrograde calculation from plasma clearance to specific clearance corrects for f_cell of the liver(fraction intracellular): CLspec = CL_pls * BW * (Q_liv+Q_pve) / (fu * (Q_liv+Q_pve - CL_pls /...

I would say: yes. Do not correct for f_cell in the CLspec equation.

From my point of view, we just need to ajust the formula with regard to back calculation. Naming etc. is fine for me. The process' name tells us that we...

The topic here is "Facilitate identification of organ permeability (in an easy fashion)" and not "adding another scaling factor" :-) A scaling factor (e.g. as simulation parameter or compound parameter)...

I am a bit surprised about the extensive discussion and agree with @PavelBal. The idea of residuals is that they represent realisations of normal distributions for a redisual error model,...

> * Are those parameters now readonly in the simulation? or can the user edit them? They are transferred to the simulation but there they are treated as usual editable...

> @sfrechen Can you please list all use cases of "compound=>simulation parameters overwriting" which have occurred so far? > E.g. when looking at the qualification plans where this have been...

And with regard to finding pathes: I think every advanced user also uses at some extent the toolboxes. Here, we do also work with pathes. I really do not see...

> Why? Michael and Juri indicated that commit and update is pretty complicated... And your suggestion is to commit it from simulations to building block. From a user perspective -...

> We identify all simulation parameters which have been "overwritten" by a compound so far Almost impossible. Will never bee comprehensive. > I don't like the static approach Would also...