Sebastian Gregoricchio

I had similar issue and I solved installing this exact version of cleanlab in my conda env: `conda install -c conda-forge 'cleanlab=1.0.1=pyhd8ed1ab_0'`

I solved the problem by substituting the numerator of the division as follows in all occurrences: ``` import numpy as np [...] inter_left_density = np.float64(inter_left_number_of_contacts_nnz) / inter_left_number_of_contacts inter_right_density = np.float64(inter_right_number_of_contacts_nzz)...

I confirm that this issue give rise to problems in comparing matrices (`hicCompareMatrices`) that have been generated by bin merging. (version 3.7.2)

@cgirardot Actually I had to regenerate the matrix from the beginning directly we the desired resolution. before I was generating a 5kb matrix, and then merging the bins to get...

> I believe that comes from some rounding in the last bin. I do not get how had issue downstream though. Can you elaborate a bit on that? Actually I...

actually I ended up in using [GENOVA](https://github.com/robinweide/GENOVA) ([RH van der Weide, *et al.*, NAR Genom. & Bioinfo., 2021](https://doi.org/10.1093/nargab/lqab040))