Help understanding causal network output

[ebasto]

Hello,

I wanted to ask for clarification regarding the output of the causal network vignette "Hypothesis-testing for CCC & Downstream Signalling Networks".

Here is my current understanding: column name (observed values when only a few) - description source - source node in the PPI, there are some values here that I don't understand ("_s","_pert_c0","_meas_c0","") source_type (unmeasured,input) - are the input nodes the receptors that were identified in the previous step? are unmeasured genes that have no expression? or genes that are not part of that receptor group? source_weight - not sure what this is, the example only has two values (0 and -4.66) source_pred_val (1,0,-1) - node is upregulated, downregulated, is zero no differential expression? target - target node in the PPI, there are some values here that I don't understand ("_s","_t","_meas_c0","") target_type (unmeasured, output) - similar to "source_type" except "output" would be TFs? target_weight - not sure what this is? the example has a few more values than "source_weight", they are all 0 or positive. target_pred_val (1,-1) - node is upregulated, downregulated? no zeros in this one edge_type (1,-1,0) - unsure what this is edge_pred_val(1,-1) - whether the edge upregulates or downregulates the target node.

Thank you in advance!

Edgar