footprints
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Published
20 hours ago •
saezlab
saezlab
Analysis code for "Perturbation-response genes reveal signaling footprints in cancer gene expression"
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footprints issues
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- [x] relationship between signalling footprints and pathway expression - [x] overlap - [x] which signal activates transcription of which pathway? - [x] ~~which pathways are more posttranslationally controlled, which...
enhancement
quite hard to find a specific script right now
enhancement
prerequesites - [x] map all scores to specific set of pathways - [x] use same pathway set input for glmnet kinds of models - [x] pathways - [x] mutations and...
todo
in progress
need to impute them using sig-only neighbourhood does that change the assocs? also, speed in general should work better with mutation-heavy tumors and CNA-heavy - can we find something interesting...
enhancement