Ron Keizer

add / improve input software checks

1

e.g. allow for Phoenix separate out in guess_software() function

binning: take into account changes in y-direction

1

not so straightforward, so probably more a long-term thing to look into. The binning approaches (either the approaches in this package or the ones from Lavielle or Uppsala) are all...

feature: bin by strata

4

have option "bin_by_strata" to allow optimized bins per strata. for both automatic and manual binning approaches

plot NPDE with uncertainty

e.g. from PKPDdatasets but with simulation data too

"red areas" as in Monolix vpc's

1

Red areas show where the observed percentile goes outside the CI area for that percentile. BTW: the red areas are a nice feature, but I'm not a fan of the...

Based upon a second simulation table in which simulation was done with uncertainty in params. Not that important actually, I don't find the VPC with uncertainty very useful as you...

feature to simulate with uncertainty

3

perhaps best to write a separate function to handle the looping over drawn parameter sets, rather than have an additional argument to PKPDsim? `sim_uncertainty()`?