pgaudet

WRT your requests: - we cannot have multiple cross references on the same GO term - at lest not for the binding, as the binding describes which specific form of...

**Catalytic activities:** - [x] Create: 3',3' cyclic-GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 3',3'-cGAMP + 2 diphosphate Xref: RHEA:35647 PMID:30787435 child of GO:0061501 - [x] Create:...

+[Term] +id: GO:0140699 +name: cyclic GMP-AMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [PMID:23258413] +synonym: "cyclic-GMP-AMP synthase activity" EXACT...

**Binding reactions:** - [x] GO:0061507 cyclic-GMP-AMP binding -> was also only annotated to 2'3', so I changed the label to 2',3'-cyclic GMP-AMP binding - [x] Merge GO:0098546 2',5-3',5'-cyclic GMP-AMP binding...

+[Term] +id: GO:0140702 +name: cyclic GMP-AMP binding +namespace: molecular_function +def: "Binding to cyclic GMP-AMP (cGAMP) nucleotide." [PMID:23258412] +subset: gocheck_do_not_annotate +is_a: GO:0030551 ! cyclic nucleotide binding +intersection_of: GO:0005488 ! binding +intersection_of:...

Still need to - [ ] ~Add RHEA:68344 to GO:0140700 3',2'-cyclic GMP-AMP synthase activity~ not adding LD for MFs yet - [ ] Add CHEBI '3'-3'-cGAMP(2-)') and '3'-2'-cGAMP(2-)') in imports...

@sylvainpoux I cannot find 3',3'-cGAMP in CHEBI - unless you want to capture this as the unspecified class https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:71501 ? Thanks, Pascale

One issue remains: We have GO:0140702 cyclic GMP-AMP binding as 'do not annotate', using ChEBI:71501 c-GMP-AMP(2−) That ChEBI has synonym '3',3'-cGAMP ', which corresponds to the child we have created,...

Asked CheBI to swap label and synonym for c-GMP-AMP(2−) CHEBI:71501 this will be less confusing https://github.com/ebi-chebi/ChEBI/issues/4296

Does that supersede the other ticket #12432 ?