paturley

Hello, MTAG will run just fine if the mean chi2 is less than 1.02, but the results will tend to be unreliable. The first step in MTAG is to estimate...

Hi Crane, I'm sorry, I don't know if I understand your question. If you have the beta and t-statistics, you should be able to infer the standard error, but you...

Sorry I don't understand your question. Is it that MTAG and LDSC are reporting different mean chi2 statistics? On Tue, Apr 7, 2020 at 12:01 AM whecrane wrote: > Hi...

I still don't understand where you are getting the numbers from. Can you attach the log files for LDSC and MTAG? On Tue, Apr 7, 2020 at 10:35 PM whecrane...

Hi Aurina, That is an interesting question. It's possible that this is a great use case, but a couple things make me nervous about it. 1) We may have myopically...

Hi Aurina, I can't think of why you couldn't do the meta-analysis in several steps like that. Seems like a reasonable strategy. Best, Patrick On Thu, Oct 21, 2021 at...

Apologies for the delays in responding to this and your other issues. I'm backlogged trying to meet a big deadline for next week. I'll respond to these as soon as...

It looks like you may need to do some data QC before passing your summary statistics into MTAG. For example, please verify that the ref and alt alleles are only...

Hello Diana, Sorry for the delayed reply here. Your email made me realize that our documentation isn't as complete as I would like, so it took a little bit of...

MTAG uses LD score regression as a backbone to meta-analyze summary statistics. I'm not a metabolite QTL expert, but my understanding is that LD score regression requires GWAS summary statistics...