paturley

Any selection on rg will potentially lead to bias, but I don't know how much bias. Maybe if you restrict to highly significant regions, it won't be as bad, but...

It won't necessarily be. MTAG estimates the genetic correlation between the two traits using the available SNPs. Given the sample of SNPs will be different for the chr1 analysis, the...

Hello Wenquiang, I'm a bit confused by your question. MTAG generates betas and p-values corresponding to each trait included in the analysis. I've seen people then use these p-values to...

Ah OK. Yes. If the traits have equal h2 and rg=1, which are the assumptions that those options impose, then the MTAG solution should produce identical summary statistics for each...

So it seems like your setting is the highest risk scenario. The pre-MTAG mean chi2 statistic for trait 1 is 1.1, but it is 1.6 for trait two, meaning that...

If I recall correctly, MTAG reports an N-weighted average of the allele frequencies across the summary stats. Can you confirm, Jon? On Wed, Aug 23, 2023, 6:24 AM Federico Murgia...

For the trait, can you calculate some summary statistics for the pval, z, and n columns (mean, median, min, max, number of observations)? On Sun, Nov 12, 2023 at 9:36 ...

What's the length of the n and z columns? (Maybe it's in there somewhere, but the format of this information is very hard to parse.) On Mon, Nov 13, 2023...

Hmm. Does it only have problems when it is trait 1 or also when it is trait 2? On Tue, Nov 14, 2023 at 12:15 AM yyfyyfzkyzky ***@***.***> wrote: >...

I believe the Price Lab has LD scores publicly available, but I'm not totally sure. We intend to post some ourselves at some point too, but I don't anticipate it...