paturley

The GWAS-equivalent N reported by MTAG just represents the "effective N" you'd need to obtain the same power in a GWAS. The effective N is a function of Ncases and...

Yeah, I was picturing something like that. Your have to explain the whole procedure in your online methods, but something like that sounds reasonable to me On Sat, Apr 6,...

Can you post the log? On Sun, Apr 7, 2024 at 3:29 AM dqq0404 ***@***.***> wrote: > Hi,sorry to bother you again. When I used the weighted formula to >...

Ah! Thanks for catching the discrepancy. It should be the effect allele frequency. On Tue, Mar 7, 2023 at 2:38 AM Divya ***@***.***> wrote: > Hi, does the --eaf_name require...

If the phenotypes are exactly negative inverse of each other (or if they have a phenotypic correlation of -1) and there is perfect sample overlap, MTAG should still work, though...

So MTAG is robust to low rg as long as its assumptions are met. So for example, if you truly believe that the effect sizes follow a bivariate normal distribution...

I believe they just searched their summary statistics for SNPs that had anything other than ATC of G as the reference or alternate allele. On Mon, Mar 20, 2023 at...

I'm fairly confident that your error implies that some SNP has a reference or alternate allele of 'AAAA'. I would run a grep on your summary statistics for 'AAAA' just...

The current MTAG software can only handle SNVs, though as you saw in another issue, it sounds like it's not too complicated to edit your local instance of MTAG to...

It depends on how comfortable you are with that high of an FDR. If you are OK with 40% of your hits potentially being false positives, then feel free to...