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Can't generate coolerfile with cload at very high resolution (200/400bp)
Hi, I am having some trouble running cload at higher resolutions (eg 200/400bp). The output freezes at the first batch of chromosomal locations and doesn't continue, even when run for a really long time? How long should it take when running cload pairix and is there anything that can be done to speed it up? Thanks!
@gdolsten do you remember if this was done with cooler cload pairix
and not cooler cload pairs
?
We are investigating and suspect the issue with very high-resolution binning and aggregation is due to quirks of Python's multiprocessing that might sometimes get triggered when data chunks reach a certain size. cooler cload pairs
does not use multiprocessing and it can be turned off for cload pairix
(or the chunksize can be reduced).