Omer Weissbrod

Thanks, the code already reads only the half-diagonal matrix (the .bcor file only stores half of the matrix). One cause for the loading time is that looping in Python is...

Hi, I suspect the reason for the slowness is simply that the ldstore code is slow. It could be made faster if it weren't written in Python but in a...

@jerome-f wow, that's crazy. I'm happy to accept a PR for this!

Good point! The code actually treats MAF as FREQ (does not assumes it's

@bschilder @AI-Murphy thanks this is awesome! I kept this ticket open for too long because I was afraid that changing the MAF column to another name would mess things up....

Hi @RaviBot, unfortunately the code doesn't support this. You can compute a combined MAF by taking the weighted average (weighting by the proportion of cases and controls in your sample)....

Hi @szhan1000, This is a good question -- what you're asking is more conceptual than technical. If you're going to apply fine-mapping using only common SNPs, there's a good chance...

Hi @szhan1000, 1) I'm not sure that most common SNPs are causal. You might want to look at some papers (e.g. Gazal et al. 2018 Nat Genet , Zeng et...

@1511878618 thanks for the bug report! Would you mind submitting a pull request with the fix you suggested? I'll be happy to merge it into the main branch. Thanks!