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[BUG] ControlFreec issues with targeted sequencing data

Open apeltzer opened this issue 3 years ago • 1 comments

Description of the bug

Running Sarek with -r dev and using a capture / targeted BED runs into trouble with ControlFreec.

https://github.com/BoevaLab/FREEC/issues/106 for more context, @FriederikeHanssen knows about it ;-)

Expected behaviour

ControlFreec just running through

Log files

Error: chromosome HLA-DRB1*16:02:01 present in your /foo/bar/baz/Homo_sapiens_assembly38.fasta.fai file was not detected in your file with capture regions wgs_calling_regions.hg38.bed
  Please solve this issue and rerun Control-FREEC

@chernomor reported it to me at BI, now reporting here so that @FriederikeHanssen has an issue

apeltzer avatar Jul 20 '22 11:07 apeltzer

Thank you! I'll try to think of a temporary work around

FriederikeHanssen avatar Jul 20 '22 11:07 FriederikeHanssen

I have added a patchy workaround in #728 . It will be part of release 3.0.2, hopefully by the end of the week. A length file containing only the relevant regions can be supplied with --cf_chrom_len .

I would close this issue, since I still have the one open in the controlfreec repository to hopefully get notified if anything changes upstream.

Let me know, if you run into any more issues regarding this!

FriederikeHanssen avatar Sep 07 '22 15:09 FriederikeHanssen