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Add additional binners

Open d4straub opened this issue 2 months ago • 2 comments

Description of feature

I am going to add some more binning tools because there seem to be very well performing binners that are not yet in this pipeline.

Currently there are 3 binners in nf-core/mag: MetaBAT2, MaxBin2, CONCOCT. In case several binners are used, bins are refined with DAS Tool.

In the CAMI 2 challenge, binners (among other tools) were benachmarked and the best performing ones were implemented into a fork of nf-core/mag (https://github.com/hzi-bifo/mag). The binners added are: MetaBinner and MetaWRAP. Additionally, UltraBinner 1 performs well.

Additionally, the benchmarking website of CAMI 2 allows continuous submission of results and evaluation. Since the publication two new binners that perform very well have been listed, see here (accessed 6th Oct 25). The binners are COMEBin & COMEBERT-2 / COMBERT-S.

Comments/discussion here or in nf-core/slack welcome.

The following (main) nf-core modules seem helpful on first glance:

  • CLAME: https://nf-co.re/modules/clame/
  • COMEBin: https://nf-co.re/modules/comebin_runcomebin/
  • SemiBin: https://nf-co.re/modules/semibin_singleeasybin/
  • VAMB: https://nf-co.re/modules/vamb_bin/

Considered binners without nf-core modules

Tentative prioritization:

  1. COMEBin
  2. MetaBinner
  3. SemiBin

The following is planned:

  • implement binners one by one to nf-core/mag (potentially via nf-core/modules)

d4straub avatar Oct 06 '25 08:10 d4straub