What causes differences in meth_qual distributions between samples?

[billytcl]

Looking at a few cfDNA samples across different runs, we've noticed instances where the meth_qual distribution can vary widely quite a bit. Eg. some samples are strongly piled up near 0 or 255, and others less so.

Since it's all cfDNA and all using the sample prep, I was wondering if there are nuances in the way remora calls methylation that we should consider or whether there is a way to bioinformatically batch correct/normalize for these differences?