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Add additional measures of heterogeneity / entropy

Open faulk-lab opened this issue 8 months ago • 1 comments

Could you add some additional measures of read heterogeneity ala "metheor"? I'm in most need of Proportion of discordant reads (PDR), as it is a measure of epigenetic erosion. The other measures are all somewhat captured by modkit's "entropy" method, but PDR is not easily calculated outside of bisulfite-converted read pipelines. I'd rather stick with using my modified bams.

I'm willing to do some testing on betas.

faulk-lab avatar May 06 '25 18:05 faulk-lab

Hello @faulk-lab,

Yeah I can look into adding that feature. It might be a few weeks since I'm slammed getting ready for our London Calling conference. I've also got some updates to entropy coming, so I'll keep you posted.

A

ArtRand avatar May 07 '25 17:05 ArtRand