Is there a way to calculate DMRs from WGBS control data/ bigwig input

[eesiribloom]

I want to calculate DMRs using a reference sample provided by a cell-type specific atlas of methylation as I do not have a matched normal bam.

Is there a way to do this using modkit if I have a .bigwig file normal file or a .beta or .pat file produced by wgbs-tools ?

[ArtRand]

Hello @eesiribloom,

Looks like the .beta files could be converted into a bedMethyl table if you can join on the chromosome and positive position of the CpG. That being said, I haven't doing any experiments with a direct comparison.