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Clarifications on DMR Analysis

Open Proy321 opened this issue 9 months ago • 14 comments

Hello @ArtRand I would like to confirm that the scores obtained in the DMR are indeed calculated based on the last two columns, i.e., pct_a_samples and pct_b_samples. Specifically, I would also like to understand the roles of the map-p value and effect size in this process. Could you please elaborate on the significance of these parameters and advise on whether we should prioritize the score, map-p value, or effect size when filtering out the most significant DMR regions? Also. i want to specifically identify dmr in 5hmC, so during pileup, should I include a flag with "--ignore C" to focus solely on identifying DMR genes associated with 5hmc? Your insights and guidance on these matters would be greatly appreciated as i strive to conduct a thorough and accurate analysis of our DMR data. Looking forward to your response.

Thanks

Proy321 avatar May 27 '24 13:05 Proy321