Marcos Díaz-Gay

Dear Kim, Thanks so much for your question and sorry for our late reply. Could you please test if you are still having this issue with the most recent [v1.1.10](https://github.com/AlexandrovLab/SigProfilerExtractor/releases/tag/v1.1.10)?

Hi again Kim, Thanks for the test, and I'm sorry you are still experiencing this issue. As you have noticed, the canfam3.1 reference genome is supported as the `reference_genome` (to...

> Just a quick follow-up question regarding the custom database. In order to re-normalize the human WSG signatures to dog, would I do: for each 96 trinucleotides, count the number...

Dear Kim, We have found a minor bug leading to the issue with the decomposition plots. It has been fixed in the newest version [v1.1.13](https://github.com/AlexandrovLab/SigProfilerExtractor/releases/tag/v1.1.13). I hope this helps, and...

Hi @guanghaoli. I'm experiencing the same issue. Can you explain how did you solve this? Where can I change the threshold value for this 'consensus pair orientation'? Thanks for your...

Dear @Ott-Alexander, Could you please share your input files/mutational matrix, as well as your JOB_METADATA file to try to reproduce your issue? Happy to help also over email at [email protected]....