Jeff Hammerbacher

Results 69 comments of Jeff Hammerbacher

@smondet can we put something on port 80 that redirects to 443?

Okay fair enough. Let's close this as won't fix then.

Actually sorry let's add something to the Ketrew documentation then close?

Wish GitHub allowed the thinking face emoji for a reaction; this feature would blur the line between workflow managers and distributed execution engines. Definitely an interesting direction to explore.

As the only open issue I could find about storing sparse arrays in Zarr, I thought I'd comment here that the AnnData project's `.h5ad` file documentation [claims](https://anndata.readthedocs.io/en/latest/fileformat-prose.html) that "Sparse arrays...

Some additional resources on other approaches to file formats for summary stats - https://www.ebi.ac.uk/gwas/docs/methods/summary-statistics - https://github.com/jinghuazhao/SUMSTATS - https://github.com/bulik/ldsc/wiki/Summary-Statistics-File-Format

https://github.com/MRCIEU/pygwasvcf is Python code to parse GWAS-VCF files but it's built with `pysam` rather than `cyvcf2`, unfortunately.

So, looking at a few example GWAS-VCF files, they're just putting per-variant sumstats into the SAMPLE fields. It appears some files use the INFO field for variant-specific metadata like minor...

Interesting, NetWAS seems to operate on per-gene summary statistics, rather than per-variant. It would be interesting to hear from the Bristol team if they've considered computing per-gene summary statistics as...

Another entry in the sumstats library and formats space: - Paper: [MungeSumstats: A Bioconductor package for the standardisation and quality control of many GWAS summary statistics](https://www.biorxiv.org/content/10.1101/2021.06.21.449239v1) (2021) - Docs: https://neurogenomics.github.io/MungeSumstats/...