dashing2 for metagenome

[jianshu93]

Hello Daniel,

I am comparing dashing2 with bindash and Mash for metagenome. I am well aware of the fact that canonical kmer was used in Mash, so that for metagenomic reads (always pair end due to sequencing), pair-end reads can be merged into one single reads by overlap detection, so that we do not need to process so many reads but only half of them since it is the same if we use canonical k-mer. I did not see a suggestion from Mash or dashing to do merge first (very fast), then we can reduce computation time to half without changing results at all. what do you think

Thanks,

Jianshu