gnotate: converting BED to VCF

[wwgordon]

Hi Brent,

I'm working on setting up a slivar pipeline with @jxchong; we have a number of annotation files that are bed formatted rather than vcf/bcf. Do you have a recommended tool for conversion? plink perhaps?

Thanks, William

[brentp]

Hi William (and Jessica), is the data of sequence-resolved variants? are there millions of variants? If so, then it makes sense to use gnotate. In that case, you'd have to write a script in python to do that. I have an example doing this for CADD (with another tool you might consider) here

If you have few sites or not variants with REF and ALT, then just use vcfanno.