Workflow for adding updated refseq alignment data

[soensz01]

I believe there have been similar questions and I'm uncertain if there was a clear recommendation about how one would go about adding new transcript data into uta for use with the hgvs module such as the data from here: https://ftp.ncbi.nlm.nih.gov/genomes/all/annotation_releases/9606/105.20201022/

Will proper functionality require that changes to the transcript sequences as well as the alignment data be available within the seqrepo data as well?

Thanks for any advice