Alex H. Wagner, PhD

Results 103 comments of Alex H. Wagner, PhD

In discussion with @rrfreimuth no better variable name was found and it was agreed that the associated `Genotype.count` description attribute sufficiently conveys the intent of this field.

Drawing this conversation from the bugfix introduced in #387. To recap the issue, the `jinja2` package was recently updated to `3.1.0`. The dev team takes a hardline approach to versioning:...

> I'm fine with expanding the scope as proposed by Alex. > > The original intention was to be able to store something that is semantically variation but not yet...

@larrybabb I think your idea of a generic Text / TextConcept entity is fine, but we will want to just have TextVariation inherit from that class in VRS if TextConcept...

The issue of `Text` as a Utility Variation concept or as a general concept should be resolved prior to release of a VRS 2.0 release candidate.

@mcannon068nw follow this thread.

I agree completely with @mbaudis above. I think this gets around many of the challenges of representing the assay signal (e.g. log2 ratios) and moves straight to the heart of...

On the upcoming 2/28 call @larrybabb and I will discuss a proposal to align the above classifications of low / high level copy number gain / loss as a Relative...

Loss-of-heterozygosity needs to be discussed in the context of genotypes.

On GA4GH call today, some concerns were stated about integer approach; confusing, and also might cause challenges when extending to other levels beyond complete / low loss / neutral /...