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feat: apply curations from mitoYeast-GEM paper

Open BenjaSanchez opened this issue 8 years ago • 1 comments
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@CarlMalina made significant curation in the mitochondrial compartment for his project. @CarlMalina would you mind sharing your changes so they can be integrated to the full model? You can make a pull request or just internally provide me with a list of changes, however you prefer

BenjaSanchez avatar Oct 25 '17 11:10 BenjaSanchez

This is now published with it's repository available here. Probably most of the changes can be directly applied to yeast-GEM.

Scripts can be found here and here.

  • [ ] Change the lipid pseudoreaction to include additional lipid species (changeLipidPseudoRxns)
  • [ ] Add new mitochondrial reactions (addMitochondrialRxns)
  • [ ] Add biotin and ubiquinol to cofactor pseudoreaction (addCofactorsToBiomass)
  • [ ] Add mitochondrial aa-tRNAs and prosthetic groups to protein pseudoreaction (changeProteinPseudoReaction)
  • [ ] Correct GPR for mitochondrial reactions (updateMitoGPR)
  • [ ] Add mitochondrial intermembrane space (IMS) compartment (addIMScomp)
  • [ ] Update compartment of metabolites in IMS reactions (correctMetLocalization)
  • [ ] Remove incorrect reactions (removeIncorrectRxns)
  • [ ] Move reactions to correct compartment, this includes adding the mitochondrial outer membrane compartment (moveReactions)
  • [ ] Represent the proton motive force (PMF) in model (addPMFcostToRxns)

More significant changes that might requires some additional discussion before inclusion: the additional compartments (mitochondrial intermembrane space and mitochondrial outer membrane) and representing the PMF

edkerk avatar Dec 10 '21 14:12 edkerk