yeast-GEM
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feat: apply curations from mitoYeast-GEM paper
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@CarlMalina made significant curation in the mitochondrial compartment for his project. @CarlMalina would you mind sharing your changes so they can be integrated to the full model? You can make a pull request or just internally provide me with a list of changes, however you prefer
This is now published with it's repository available here. Probably most of the changes can be directly applied to yeast-GEM.
Scripts can be found here and here.
- [ ] Change the lipid pseudoreaction to include additional lipid species (
changeLipidPseudoRxns) - [ ] Add new mitochondrial reactions (
addMitochondrialRxns) - [ ] Add biotin and ubiquinol to cofactor pseudoreaction (
addCofactorsToBiomass) - [ ] Add mitochondrial aa-tRNAs and prosthetic groups to protein pseudoreaction (
changeProteinPseudoReaction) - [ ] Correct GPR for mitochondrial reactions (
updateMitoGPR) - [ ] Add mitochondrial intermembrane space (IMS) compartment (
addIMScomp) - [ ] Update compartment of metabolites in IMS reactions (
correctMetLocalization) - [ ] Remove incorrect reactions (
removeIncorrectRxns) - [ ] Move reactions to correct compartment, this includes adding the mitochondrial outer membrane compartment (
moveReactions) - [ ] Represent the proton motive force (PMF) in model (
addPMFcostToRxns)
More significant changes that might requires some additional discussion before inclusion: the additional compartments (mitochondrial intermembrane space and mitochondrial outer membrane) and representing the PMF