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RFE: Allow subsetting samples in the GISTIC class

Open lbeltrame opened this issue 4 years ago • 3 comments

As the issue subject says, it might be useful to subset samples in GISTIC objects, similar to what it is done for MAFs. A use case I have is a global analysis I made with GISTIC, but I want to display the individual alterations in two different oncoplots basing on some clinical data.

lbeltrame avatar May 25 '20 08:05 lbeltrame

I have been trying to implement it but it seems it does not make sense to subset GISTIC object because the statistics such as p-values, amplitude, g-scores, etc are all estimated on the original cohort and can not be subsetted (or recalculated in R). Even you subset for specific samples you will end up with faulty values.

PoisonAlien avatar Jun 14 '20 09:06 PoisonAlien

If it is truly important, maybe we can consider providing GisticCompare for two or more gistic objects. It should make sense.

ShixiangWang avatar Jun 14 '20 10:06 ShixiangWang

Yeah something like GisticCompare should be a better option. Also you can just add clinical parameter as one of the annotation row which should be suffice and show the differences between groups.

PoisonAlien avatar Jun 14 '20 13:06 PoisonAlien

This issue is stale because it has been open for 60 days with no activity.

github-actions[bot] avatar Sep 10 '23 02:09 github-actions[bot]

This issue was closed because it has been inactive for 14 days since being marked as stale.

github-actions[bot] avatar Sep 24 '23 02:09 github-actions[bot]