TCGAmutations
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Request for additional metadata: Capture Kit
Hi,
Just wondering about feasibility of adding additional sample metadata, for example which capture kit was used?
Reason we care about capture kit:
Capture kit biases have led to false negative mutation calls in multiple TCGA cohorts. Variability in the capture kits used can contribute to inter-cohort TMB variation. More importantly, there are some genes that may be mutated in a sample, but whose mutation you will/won't see because of the specific capture kit that was used. See Wang et al. 2018 for details