Jia21

> Hi Elaine, > > Yes, we need at least two replicates for cell type proportions because we need to calculate cross-subject variance. > > Best, > Xuran Hi Xuran,...

Hi, I met the same warning issue. I am wondering whether it's a big issue for CNV calling. Thanks! Elaine

> Can you turn on `verbose = TRUE` and see if there are any numerical or convergence issues? Yes, Here is the log information. I specified two SNPs as examples...

> 31.941050586 > [6] 31.307497606 31.713237746 31.767771860 31.818582502 31.811060479 > [11] 31.736427430 31.884654203 31.912535230 32.019469464 31.632941611 > [16] 32.201665511 31.829010417 32.261927793 31.777219632 31.396711665 > [21] 31.963521855 31.207691174 31.354248461 32.058397332 I...

> I would suggest that you talk to your collaborator who created these variables and see what your options are. This is not a specific problem for GLMMs. If you...

There are 1174 individuals and 1849 bi-allelic SNPs in my data.