JacobRPrice

> Here is a snippet of some code that I used when I was trying to run a comparison on Miseq data and simulated NovaSeq data that I created by...

# A follow up to my original post: I ended up trying a couple of different additional approaches/variants of a modified `loessErrfun` to see what the outcomes would look like....

Hi @benjjneb and @Y-Q-Si, I sent an email briefly describing the data and shared a google drive link to the raw data as a tarball. Please let me know if...

@andzandz11 The error you're seeing is most likely due to a single (or perhaps more) unique sequence(s) within your dataset. In your issue (#1343), your quality profile plots shows that...

I'll second Jeff's request. I'd love to hear any recommendations official or otherwise. We have several NovaSeq datasets that are currently tabled.

@nejcstopno , IMHO testing on a 10% subset should give you a pretty good idea of what the outcome would be for the full dataset. As far as your choice...