Scores generated by newer GPUs are very odd.

[Luobiny]

Dear SpliceAI developers,

When running on newer GPUs (RTX 3090, Telsa A100 etc.), SpliceAI generates scores totally different from scores generated on CPU for the same VCF. Also there are many 'nan' scores. For example, there are many lines like the following in the output:

1 1123785 . A ATT 46.85 SpliceAI SpliceAI=ATT|TTLL10|nan|nan|nan|nan|-50|-50|-50|-50 3 52996994 . GTTATTTTATT G 181.48 SpliceAI SpliceAI=G|SFMBT1|nan|nan|nan|nan|-50|-50|-50|-50 3 53074984 . A ATTT 7.47 SpliceAI SpliceAI=ATTT|SFMBT1|nan|nan|nan|nan|-50|-50|-50|-50

However, when running on a bit old GPUs (RTX 2080ti, Tesla P100 etc.) using the full input VCF (about 168K variants), SpliceAI generates the same scores as running on CPU...

[kishorejaganathan]

Thanks for bringing this to our attention, will update the package with a fix shortly.

[zyh4482]

I have the same issue. I'm working on CPU. In my case, I have two point mutations, the distance between them ranged from zero to ~20nt. I thought SpliceAI does not accept such variant input...

[bjtrost]

Thanks for bringing this to our attention, will update the package with a fix shortly.

Hi,

Was a fix found/implemented for this?

[durtschi]

Hello, We are having the same issue. What is the outlook for an update to fix this?

[drmurdock]

@kishorejaganathan, was this issue ever fixed? I'm getting the same problem running on a RTX 3060 Ti, even with a fresh install of spliceai. All the variants are scored "nan|nan|nan|nan|-50|-50|-50|-50". Thanks.