Devlin Moyer
Devlin Moyer
I'm working on a new semi-automated model curation tool that identifies reactions that form loops capable of sustaining infinite fluxes, and one such loop was phytanic acid [c] -> phytanoyl-CoA...
But also, after you suggested that I split #634 into multiple issues in #726, I noticed that several of the mitochondrial reactions that were associated with peroxisomal genes seemed like...
Fixed by #792
I did FVA on version 1.18 of Human-GEM, made the proposed changes to the [c] [m] thiamine transport reactions, did FVA again, and found that there were only 2 reactions...
that paper says tagatose is "metabolized in the liver by the same route as fructose", and a quick look through papers that mention fructose metabolism in livers (e.g. [this one](https://doi.org/10.1093/ajcn/58.5.754S))...
sorry I may not have written that super clearly; 3(S)-Phytanoyl-CoA (`MAM03362`) is the same as phytanoyl-CoA (`MAM02747`), and 3(S)-2-Hydroxyphytanoyl-CoA (`MAM03363`) is the same as 2-hydroxyphytanoyl-CoA (`MAM00655`)
I just came across [this paper](https://doi.org/10.1016/S0022-2275(20)30150-4) that mentions that people's diets usually consist of a racemic mixture of (3S)- and (3R)-phytanic acid, and while the enzymes responsible for the alpha-oxidation...
I edited the proposed changes to try and accurately reflect the stereochemistry that's relevant to these reactions
MAR09985 and MAR11307 were addressed in #588/#623 MAR02358 was removed for being a duplicate of MAR08482 in #657 MAR01364, MAR03880, MAR03964, MAR07799 and MAR00080 don't appear to have been mentioned...