Jose L. Cadavid

This is an issue I am very interested in. I think one question to reconcile is how we define and check for tasks, since the Richelle et al paper does...

Thanks for your answers, those issues were clear to me. I should have been clearer: What I mean is that the way tasks are checked in [this](https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006867) related paper by...

Friends, I made a quick function to check the tasks by constraining only input and output fluxes by creating temporary exchange reactions involving only the metabolites in either inputs or...

Using this approach of relaxing the boundaries on the outputs, the following tasks now pass: 'Deoxyguanosine triphosphate synthesis (dGTP)' 'Deoxyuridine triphosphate synthesis (dUTP)' 'Deoxythymidine triphosphate synthesis (dTTP)' 'Arginine synthesis' 'Aspartate...

@Hao-Chalmers I'll have to look at this pathway in detail, it is [more complicated](https://reactome.org/PathwayBrowser/#/R-HSA-1650814&SEL=R-HSA-2089971&PATH=R-HSA-1474244,R-HSA-1474290) than I thought. Procollagen seems to be [exported in vesicles](https://journals.biologists.com/jcs/article/118/7/1341/28724/Procollagen-trafficking-processing-and) and it matures fully outside the...

More generally, I found [this](https://www.nature.com/articles/s41467-019-13867-y) paper (with input from your group) that looks at incorporating protein export. Maybe this is an even better thing to integrate?

@mihai-sysbio other than my previous comment, I haven't been able to spend too long on this since I am trying to get experiments to graduate this year. Terribly sorry about...