Amelie Schreiber

EsmForSequenceClassification does not support gradient checkpointing

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NOTE: if this is not a bug report, please use the [GitHub Discussions](https://github.com/facebookresearch/esm/discussions) for support questions (How do I do X?), feature requests, ideas, showcasing new applications, etc. **Bug description**...

I was just wondering if perhaps training with linker tuning or by inpainting intrinsically disordered regions (IDRs) using EvoDiff might help with data quality. Using linker tuning as was done...

ESM-2 implementation?

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Any chance there will be an update to use ESM-2 models such as `facebook/esm2_t6_8M_UR50D`? This would make the code easier to use locally for people who have hardware constraints, and...

Using Masked Marginal Score for ESM-2 as a Scoring Method

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In the paper [Language models enable zero-shot prediction of the effects of mutations on protein function](https://www.biorxiv.org/content/10.1101/2021.07.09.450648v2) the ESM folks introduce the "Masked Marginal Scoring" method to compute effects of mutations...

Running the `evodiff/generate.py` script

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I've been having trouble with getting the conda environment to work properly, so this may be exacerbating the issue below. ``` (evodiff3) ubuntu@209-20-159-77:~/evodiff_repo$ python evodiff/generate.py --model-type oa_dm_38M --num-seqs 100 Traceback...

Collaborate

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I'm very interested in replicating your work and would like to train a diffusion model to generate protein binding partners similar to what RFDiffusion accomplishes, but I would like to...