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igv.js view on variant details page does not "jump" to SV position

Open flokraft85 opened this issue 3 months ago • 0 comments

Describe the bug The IVG view on the variant details page for SV (GRCh38) shows the whole genome (chr1-22, X and Y) instead showing the region, where the SV is localized. Region is set to all. I can enter the position manually in the IGV view (eg chr1:20,605,522-20,606,197) and then the IGV jumps to the correct position. However, the tracks which are shown for GRCh37, eg DGV, gnomAD SV ... are not visible. Maybe the bed files for the tracks are missing for GRCh38? Something really weird happened, if I scroll during loading of the SV variant details page. Then the IGV view shows the "right" position, but with the hg19 genome build. Which is of cause then the wrong position in this genome build. Maybe related to https://github.com/varfish-org/varfish-server/issues/1525

To Reproduce Steps to reproduce the behavior:

  1. open a case
  2. click on "Filter SV"
  3. click on "Filter&Display"
  4. click on a variant in the list
  5. scroll to IVG view on variant details page

Expected behavior IGV view should show the position matching to the SV and should show tracks indicating SV in this region from gnomAD SV, DGV etc.

Screenshots IGV view only show "all" grafik IGV view after manually entering the position grafik IGV view with hg19, after scrolling during variant details page loading grafik

Desktop (please complete the following information):

  • OS: Win10
  • Browser Firefox
  • Version 124.0.0

Smartphone (please complete the following information): n/a

Additional context n/a

flokraft85 avatar Apr 19 '24 13:04 flokraft85