Different resolution produce different result

[biozzq]

Dear all

According to your published paper, I defined regions with a z-normalized similarity score ≤−1.2 and a signal-to-noise ratio of r ≥ 0.6 as the significant changing. When using 40kb resolution, I can indentify some changing regions. However, it is difficult to catch any any significant changes in the interaction heatmap in these regions. Continuing from the previous discussion (https://github.com/vaquerizaslab/chess/issues/34), @liz-is has given us some suggestions to adjust appropriate parameters. Thus, I tried 25kb resolution. In this case, no region can be identified as changing regions.

Does this mean that there is no significant changes in 3D organization of chromatin between these two samples?

Best regards, Zheng zhuqing